Phenotyping resistant hypertension: exploring a multi-omic interrelation in the pathophysiology of resistant hypertension (RH)

Project title
Phenotyping resistant hypertension: exploring a multi-omic interrelation in the pathophysiology of resistant hypertension (RH)

People involved
Principal investigator: Prof. Ntobeko Ntusi, Prof. Adrian Brink and Dr. Fadheela Patel
Postgraduate Researcher: Pheletso Letuka
Bioinformatics support team: Ephifania Geza

Short description of project
This study aims to investigate whether microbial dysbiosis, heightened inflammation, and distinct proteomic signatures contribute to inadequate blood pressure control in resistant hypertension. The research will compare healthy individuals, patients with controlled hypertension, and those with uncontrolled resistant hypertension. Using a comprehensive multi-omics approach, the study integrates gut microbiome profiling through 16S rRNA amplicon sequencing, targeted proteomics via Luminex cytokine panels, and global proteomics using Liquid Chromatography–Mass Spectrometry (LC-MS).

Research Group
Ntusi Research Group/Medicine