Overview
Project title
Lactobacillus iners MAGs: Genital inflammation in adolescent women
People involved
Support requested by: Adijat Jimoh
Principal investigator: Dr. Anna-Ursula Happel, Prof. Heather Jaspan
Bioinformatics support team: Ephie Geza, Gerrit Botha
Short description of project
This study emanated from the following questions
- What is the evolutionary relationship between Lactobacillus iners (L. iners) Metagenome-Assembled Genomes (MAGs) found in the vagina of women with genital inflammation and those without
- Are there are functional pathways that are associated with L. iners strains in adolescent women with low vs high genital inflammation ( or do certain pathways drive transitions from low to high genital inflammation or vice versa?
- Which MAGs are shared within participants across time points? Do the same L. iners strains/MAGs remain present when genital inflammatory or BV status changes, or do other strains / MAGs appear?
The data include metagenomes from 38 samples, that is, 13 participants (12 with three time points each and one with two time points).
Objectives
- To discover the L. iners strains that are associated with genital inflammation (and bacterial vaginosis)
- To determine functional gene pathways, similarities/differences associated with high and low genital inflammation in adolescent women
- To identify shared genetic relationship/abundance of Lactobacillus iners strains across different longitudinal time points
- Department: Other