HIV latency transcriptomics of resting CD4+ T cells

Project title
HIV latency transcriptomics of resting CD4+ T cells

People involved
Principal investigator : Walter Nevondo
Bioinformatics support team: Katie Lennard

Short description of project
Despite anti-retroviral therapy HIV persists in a latent form of replication‐competent genome in anatomical and cellular reservoirs. This study has the following specific questions:

1. What is the permissive cellular environment that facilitates HIV-1 productive and latent infection?
2. What are the cellular regulatory mechanisms of HIV-1 latency maintenance and persistence?
   • Is latency maintained through global or cell-specific mechanisms?
   • Are there other novel mechanisms responsible for HIV-latency maintenance?
3. Does HIV-1 infected resting CD4+ T cells show specific transcriptional signature and is there any surface marker unique to these cells?

Objectives
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